MT1

MT-1 — Linear Melanocortin Receptor Agonist

MT-1 (Melanotan I) is a synthetic linear tridecapeptide analog of alpha-melanocyte stimulating hormone (α-MSH), featuring amino acid substitutions that enhance metabolic stability while maintaining the linear peptide structure. Unlike cyclic analogs such as MT-2, the linear structure of MT-1 provides a more selective melanocortin receptor binding profile, making it a valuable tool for MC receptor subtype studies.

Mechanism of Action

MT-1 demonstrates preferential binding to MC1R, the melanocortin receptor subtype primarily responsible for eumelanin synthesis in melanocytes. Upon MC1R activation, the Gs/cAMP/PKA signaling cascade phosphorylates CREB, which upregulates MITF transcription and downstream melanogenic enzymes including tyrosinase, TRP-1, and TRP-2. This targeted MC1R profile distinguishes MT-1 from non-selective melanocortin agonists that simultaneously activate MC3R-MC5R.

Research Applications

• MC1R-selective melanocortin signaling studies
• Melanogenesis and eumelanin biosynthesis research
• Melanocyte biology and pigmentation mechanisms
• Comparative studies with cyclic melanocortin analogs
• Photoprotection and UV response pathway research

Product Specifications

• Quantity: 10mg per vial
• Purity: ≥99% (HPLC verified)
• Form: Lyophilized powder
• Storage: Refrigerate after reconstitution